In this video, Dr. Adwaita A. Gore, Medical Oncologist at S L Raheja Hospital, Mumbai, presents a real-world case highlighting the management of chemotherapy-induced anemia (CIA) in a patient with metastatic breast cancer receiving CDK 4/6 inhibitor–based therapy.The case features a 65-year-old post-menopausal woman with ER-positive, HER2-negative metastatic breast cancer, who achieved good disease control on letrozole and palbociclib but developed severe, symptomatic anemia during prolonged treatment. Chemotherapy-induced anemia is a common yet often under-recognized complication that can significantly impact quality of life and treatment continuity.Dr. Gore discusses how timely intervention with an erythropoiesis-stimulating approach, supported by iron supplementation, led to a progressive improvement in hemoglobin levels from 6.7 g/dL in January 2025 to 9.8 g/dL by June 2025, with meaningful improvement in fatigue and overall quality of life—without the need for blood transfusions.Watch the full video to gain practical clinical insights into the real-world management of chemotherapy-induced anemia in metastatic breast cancer and how structured anemia correction can support uninterrupted cancer therapy and improved patient outcomes.