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Good morning. In perhaps the most exciting development of the new year,  STAT has launched a daily mini crossword. I completed yesterday’s in 22 seconds — let me know what time you get.

The need-to-know this morning

Alumis said envudeucitinib, its oral TYK2 inhibitor, achieved multiple skin-clearance efficacy goals in two Phase 3 clinical trials involving patients with plaque psoriasis. The company plans to submit the drug to the FDA in the second half of the year. 

Bright Minds Biosciences announced positive seizure-reduction results from a mid-stage study of its epilepsy drug candidate BMB-101.

Arrowhead’s RNAi drugs cut fat in early studies

Arrowhead Pharmaceuticals said this morning that its gene-silencing candidates helped people with obesity lose fat. The early results may heat up the competition to develop longer-lasting weight loss treatments, but more data are needed to determine whether the drugs have a place in the existing obesity market.Continue to STAT+ to read the full story…

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